Researchers have explained that rapid, accurate, and mass detection of the virus is an important measure to combat infectious diseases such as coronavirus. A new strategy for the diagnosis of viruses using reactive double-stranded RNAs can serve as preliminary screening with increased sensitivity for a wide range of viruses.
It was developed at the Korea Institute of Advanced Technology. A research team led by Prof. Sheng Li and Prof. Yusik Kim from the Department of Chemical and Biomolecular Engineering has created a universal virus detection platform using the distinctive features of its granular surface.
The main idea of the platform is to use the features of granular polymers that mobilize the functional groups of molecules. Since double-stranded RNAs are common byproducts of transcription and replication of viruses, these surfaces can help detect viruses without examining their genomic sequences.
To increase the sensitivity to viruses, a team of researchers has developed an analog of a two-step process for the detection of immunosorbent analysis. In this case, the bound double-stranded RNAs are visualized using fluorescently-labeled antibodies.
Using the developed platform, long double-stranded RNAs can be detected and visualized from a mixture of RNAs, as well as from total cell lysates that contain a mixture of various substances, such as DNA and proteins. Using this tool, a team of researchers successfully detected elevated levels of hepatitis C and A.