Artificial intelligence has discovered 10 drugs to stop the reproduction of a new type of coronavirus in human cells. This was reported by the press service of the development company of the neural network, the biological startup Gero.
Gero Artificial Intelligence has analyzed the effects of various drugs and their potential use in the fight against SARS-CoV-2 coronavirus.
The developers’ calculations were based on the fact that the causative agent of SARS, a close relative of this SARS-CoV-1 virus, uses the COPI enzyme, which is found in human cells, to form new viral particles. Under normal conditions, this protein is involved in sorting other amino acid chains and packing them in special transport capsules. However, the virus changes its work and uses N to produce protein, a key part of its envelope.
Experiments have shown that if you block the operation of COPI, you can prevent the virus from multiplying. With the help of this neural network, scientists analyzed a thousand already created drugs of various kinds and found 18 drugs that could suppress COPI activity. At the same time, 8 of them were recognized as unsafe for humans, therefore, artificial intelligence focused on working with 10 drugs.
Two drugs from this list – niclosamide and nitazoxanide – originally created to combat parasitic worms, are already recommended for experimental treatment of patients in France and Singapore from coronavirus.