Swiss molecular biologists have created an analog of the heart of a mouse embryo from stem cells.
The main plus of embryonic organelles is that many different tissues develop in parallel inside them. They exchange with each other the same signals that are critical for the correct growth of the embryo. The heart cells growing in them are in the same environment in which they would be located in a real embryo.
Juliana Rossi, molecular biologist at the Swiss Federal Polytechnic School and one of the authors of the work.
Experiments with universal stem cells have been going on for several years: scientists have already tried to grow, for example, an analog of the liver with their help.
Rossi’s team has taken the first big step towards organ culture in vitro.
A team of scientists analyzed the sets of signals that are needed for stem cells to start converting into specific tissues in the body. And the heart is the first organ that forms inside the embryo of multicellular organisms. Accordingly, the researchers decided to grow not a full-fledged heart, but its embryo.
The finished organ, which turned out as a result of the work, began to contract, and also to generate and perceive signals characteristic of a developing heart. It is also noted that blood vessels began to grow around the organ.
The work continues, scientists intend to improve their developments in order to grow a human heart in the future.