The authors of the new work studied different types of materials in order to perform bone grafting as efficiently as possible.
Injuries to the bones of the face and skull are difficult to repair because different types of cells must interact during this healing process. The authors of the new work studied several materials that they use during the operation to understand which one works best.
More than 2 million bone transplant operations are performed worldwide every year. Usually, in this case, they are often restored with the help of regenerative biomaterials.
The researchers adapted the collagen biomaterial and studied how it affects processes important for bone regeneration, such as stem cell activity, immune cell activation, and endothelial cell activity. These are all important for the formation of new blood vessels.
The researchers tracked the growth of endothelial cells over 6-12 hours. As a result, the medium, which was generated by the stem cells in the frameworks of chondroitin-6-sulfate, began to form blood vessels the fastest in comparison with the rest.
The authors note that in their new work, they proved that there are differences in the reactions of cells depending on what material is used. It is important to understand these interactions before moving on to more complex experiments.