Researchers at the UCL Cancer Institute and the London Institute of Medical Sciences studying errors in protein structure have found a direct link between the number of errors in protein structure and longevity.
The authors of the new work decided to check what will happen if the number of errors in DNA is reduced: whether this will affect the health and lifespan of organisms.
But errors in proteins are usually neglected, despite the fact that errors that occur during the synthesis of new proteins are much more common than mutations that occur during DNA replication.
Ivana Biedov, Doctor and Project Manager
For the experiment, they used hyperthermophilic archaea – these are single-celled organisms that can live at extremely high temperatures. They have a mutation in their ribosomes that increases the accuracy of protein synthesis.
Then the authors reproduced the mutation in the ribosomes of multicellular animals – yeast, worms and fruit flies.
As a result, it turned out that after the implantation of the mutation, there were fewer errors in the organisms, and they received increased heat resistance and lived longer.
This is the first study to confirm that reducing protein errors can improve health outcomes and prolong life.