Specialists from the University of North Carolina were able to neutralize the coronavirus thanks to special nano traps.
The mechanism of infection with SARS-CoV-2 works as follows: with the help of a spike protein, the virus clings to the angiotensin-converting enzyme 2 (ACE2) on the cell surface and penetrates it. To deceive him, the experts made particles from human lung spheroid cells (LSCs) with the same ACE2 receptors. These particles become multiple false targets for the coronavirus, preventing it from infecting the body and multiplying in it.
Scientists tested this treatment method first on mice, and then on macaques. Nano traps were delivered to the animals by inhalation therapy. LSC-baits reduced inflammation and fibrosis in the lungs, as well as accelerated the process of removing the virus from the body.
This method of treatment has several advantages. First, nano traps can be delivered to the human body by non-invasive methods, using inhalation. Secondly, baits can be stored for a long time. Third, the same LSCs are used in other clinical trials, so we can assume that they will be used soon.
“By focusing on protecting the body, rather than on the virus itself, which continues to mutate, we were able to develop a therapy that will be effective for a long time,” concluded one of the study participants.