Many years after the discovery, an international team of scientists managed to figure out how the tuberculosis bacterium “dodges” the treatment and the immune response.
Mycobacterium tuberculosis survives iron deficiency by using rubredoxin B, a protein from the rubredoxin family. They play an important role in the adaptation of organisms to changing environmental conditions. The research results are published by the journal Bioorganic Chemistry.
According to the World Health Organization (WHO), every year, 10 million people contract tuberculosis, and about 1.5 million die from it. The bacterium that causes tuberculosis, Mycobacterium tuberculosis, is known for its ability to survive in macrophages. These are cells of the immune system that destroy harmful bacteria that enter the body. The spread of drug resistance of M. tuberculosis to widely used therapeutic agents has become a significant clinical problem in recent decades. In this regard, the identification of new molecular drug targets and the deciphering of the molecular mechanisms of drug resistance are critical.