Microparticles are a new way to deliver the drug in several doses at the same time: these smallest particles can be designed to begin to act at certain intervals. However, microparticles are not so easy to enter into the body, they can clog in a regular syringe. Scientists have found a way to avoid this, according to Science Advances.
The size of the microparticles is from 1 to 1000 microns (millionths of a meter). Many researchers are working on the use of microparticles made from polymers and other materials for drug delivery. The FDA (US Food and Drug Administration) approved about a dozen of these dosage forms, but the rest have not been successfully tested because they are difficult to enter.
Researchers at the Massachusetts Institute of Technology have developed a computational model that can make an injection of microparticles more effective and prevent clogging of the syringe. The model analyzes many factors, including particle size and shape, to determine the optimal design for injection.
Using this model, the researchers six times increased the percentage of microparticles that successfully enter the body.
This is a model that can help us with new technologies that we have developed in the laboratory, and which we are trying to introduce into the clinic.
Ana Yaklenets, Researcher at the Institute of Integrative Cancer Research named after Koch at the Massachusetts Institute of Technology.
Researchers are now hoping to use the model to develop and test microparticles that “deliver”, for example, drugs for cancer immunotherapy.