Scientists from NUST MISIS and specialists from the State Scientific Center for Applied Microbiology and Biotechnology and the Institute of Biochemistry named after Bach developed nanoparticles for targeted delivery of an antibiotic to the site of infection.
Scientists note that the consumption of antibiotics is now growing all over the world. In order to reduce the amount of their consumption and prevent the consequences, the authors turned to antimicrobial nanohybrids. The main advantage of such drugs, according to scientists, is a serious decrease in the dose of the antibiotic, which reduces the load on the body and slows down the development of resistance in microbes.
So scientists created nanoparticles based on hexagonal boron nitride with silver particles: they showed high bactericidal and antifungal activity.
H-BN nanoparticles with a size of 100 nm are obtained by chemical vapor deposition, then silver particles are deposited on them by ultraviolet decomposition of silver nitrate. The nanoparticle cavities are saturated with antibiotics, which, after administration of the drug, gradually enter the body within nine days.
Christina Gudz, engineer of the laboratory “Inorganic nanomaterials”, NUST “MISIS”
The researchers argue that the resulting nanohybrids are capable of destroying bacterial and fungal populations with a much lower active substance than antibiotics currently on the market. Sometimes the difference reaches 6-7 times.