New device can accurately reproduce tissue

The new bioprinting method uses the aspiration of tiny cells and tissues to precisely place them in 3D patterns and create artificial tissues. Their properties are very close to natural, scientists from the University of Pennsylvania state.

“Tissue spheroids are increasingly being used as building blocks for fabrics, but their accurate bioprinting was a problem that we could not yet overcome,” said Ibrahim Ozbolat of the University of Pennsylvania, who worked on this device. “In addition, these spheroids were primarily applied without the use of bioprinting and could not be used to make other fabrics”.

Their use is necessary in many areas of regenerative medicine and tissue engineering, as well as in the manufacture of microphysiological systems for modeling diseases or screening drugs. Ozbolat and his team used aspiration bioprinting along with conventional printing to create homogeneous tissues and tissues containing various cells.

Suction bioprinting uses suction to move tiny microscopic spheroids. Aspiration bioprinting picks up the tissue of the spheroid, holds it by absorption until it is placed in the right place. Researchers talked about the details of their work in the journal Science Advances.

“Of course, we must gently absorb spheroids in accordance with their properties so that there is no damage when transferring spheroids to a gel substrate”, said Ozbolat. “They must be structurally intact and biologically viable”.

By controlling the exact placement and type of spheroids, the researchers were able to create samples of heterocellular tissues containing various types of cells.

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