It turns out that coronavirus prevents cells from recognizing it

With the help of the alarm code, we can enter the building without calling. It turns out that the SARS 2 coronavirus (SARS-CoV-2) has the same benefit when it enters cells. He has the advantage of entering cells. On July 24, in the journal Nature Communications, researchers at the Health Sciences Center at the University of Texas at San Antonio reported how the coronavirus is doing this.

Scientists have identified the structure of an enzyme called nsp16, which the virus produces and then uses to modify its surface with messenger RNA.

This is camouflage. Due to the modifications that trick the cell, the resulting viral RNA is now considered part of the cell’s own code, rather than foreign.

Dr. Yogesh Gupta, lead study author from UT Health School of Medicine

In simple terms, messenger RNA can be described as a supplier of genetic code to jobs that produce proteins.

Deciphering the three-dimensional structure of nsp16 paves the way for the rational design of antiviral drugs to treat COVID-19 and other emerging coronavirus infections, Dr Gupta said. The drugs, new small molecules, will prevent nsp16 from being modified. The immune system can then attack the invading virus, recognizing it as foreign.

Yogesh’s work uncovered the three-dimensional structure of a key enzyme in the COVID-19 virus, which is required for its replication, and found a “pocket” in it that can be used to inhibit this enzyme. This is a fundamental advance in understanding the virus today, scientists say.

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