American scientists have found that there are genetic risk factors that make people more susceptible to severe COVID-19.
It is impossible to predict in what form a person will tolerate COVID-19: severe or mild? Doctors still do not know what it depends on.
Researchers at the Beth Israel Deaconess Medical Center in Boston, led by Robert Gerszten, M.D., head of the center’s cardiovascular medicine department and professor at Harvard Medical School, decided to link the severe course of the coronavirus and the structural features of genes.
Patients with COVID-19 show a wide range of clinical manifestations, from flu symptoms to acute respiratory infections. It is known that cardiovascular and metabolic diseases are risk factors, but it is not clear why some people have a life-threatening illness, and some do not.
The authors looked at the genomes of 4,856 patients from China, Europe, and the United States who had had COVID-19 and found variations in the two regions that determine the disease’s severity. They then identified which proteins encode these regions of the genome and what role these proteins play in the body in the context of disease.
It turned out that one of the two regions of the genome was associated with the CD209 antigen. It is a protein by which the coronavirus penetrates and infects human cells. Another point was related to the poorly understood protein CXCL16, which scientists believe helps distribute immune cells to infection sites.
The authors believe their work will help better understand how to deal with a new disease.