The company is developing a vaccine in collaboration with researchers from the University of Oxford.
According to a detailed analysis conducted by independent British scientists, the COVID-19 vaccine developed by scientists from Oxford and AstraZeneca precisely follows the genetic instructions programmed by its developers to trigger a strong immune response successfully.
“The vaccine does everything we expected, and this is good news in our fight against the disease,” said David Mathews, a Virology expert at the University of Bristol who led the study.
AstraZeneca, which is developing a vaccine with researchers from the University of Oxford, is considered one of the race leaders to create a COVID-19 vaccine.
It is expected that the first results of large-scale late-stage clinical trials conducted in several countries around the world, including Brazil, the United States, and the United Kingdom, will be published before the end of the year.
The vaccine, known as ChAdOx1 or AZD1222, is made by taking chimpanzee adenovirus and removing about 20 percent of its instructions. Because of this, the vaccine will not be able to reproduce or cause the disease in humans.
The Bristol researchers focused on evaluating how often and how accurately the vaccine copies and uses the developers’ genetic instructions. These instructions detail how to get spike protein from the SARS-CoV-2 coronavirus that causes COVID-19.
Once a spike protein is formed, the immune system responds to it, training the immune system to detect a real COVID-19 infection.
“This is an important study because we can confirm that the genetic instructions underlying this vaccine… are correctly followed when they enter a human cell,” Mathews said.
His group’s research has not yet been reviewed by other scientists but was published as a preprint before the review.