Coronavirus tests will use the new RNA imaging technology. A method called Mango will improve cell screening for viruses, as it will “highlight” individual sections of RNA in them. This is stated in a study by scientists from Simon Fraser University, who received funding from the Canadian Institute for Health Research (CIHR) to develop new texts. About this writes Nature.
The Mango system consists of an RNA aptamer that binds tightly and specifically to a fluorescent dye. The aptamer acts like a magnet, directing and binding these dye molecules. During this process, the dye becomes excitable and upon detection of the target fragment begins to glow brightly.
RNA molecules modified in such a way that they contain an aptameric magnet are isolated from non-target parts of the cell – this greatly facilitates the study of the RNA molecule under a microscope.
Mango NABSA kits can be used to test for coronavirus, which is a RNA virus with a positive chain, the authors of the study note.
“Cell regulation occurs at the level of RNA. For a long time, the main focus was on the protein, but it is RNA, not protein, that regulates the vast majority of processes in the cell. Mango’s technology is state-of-the-art, and developing effective cancer drugs and tests for a variety of viral diseases requires more advanced imaging techniques to quickly learn how cells work in detail”.
Peter Unrau, lead author of the study