Scientists in Costa Rica are developing anti-SARS-CoV-2 drugs based on horse antibodies. Writes about this publication Scientific American.
During the studies, the animals were injected with the SARS-CoV-2 proteins formed in the laboratory. At the same time, three of the horses received only a certain proportion of the protein, while the others received a combination of four coronavirus proteins.
After four shots every two weeks, the horses developed the correct antibody level.
At a pharmaceutical plant, researchers isolated the antibodies and purified them to create a therapeutic compound for human trials. In total, the enterprise produced a thousand vials of purified equine antibodies with a volume of 10 ml. Half of them had protection against spike protein, the other contained four proteins present in the coronavirus.
According to the lead researcher of the project, a microbiologist at the Claudomiro Picado Institute Alberto Alape Girona, one bottle of horse antibodies will cost about $ 100, and preparations based on human antibodies will be 10 times more expensive.
Just one 10 ml vial contains approximately 80 times more antibodies than can be found in 800 ml of convalescent plasma, i.e. plasma provided by someone who has overcome SARS-CoV-2 infection
Alape Girona, lead investigator of the project, microbiologist at the Claudomiro Picado Alberto Institute