However, visitors will have to comply with strict restrictions, including those relating to the worship of shrines.
Church of the Nativity in Bethlehem, built on the site where Christians believe Jesus Christ was born, reopened on Tuesday after more than two months of interruption caused by the coronavirus epidemic.
Several priests from different Christian denominations watched as a Church in the Israeli-occupied West Bank opened its doors.
The Church has been closed since March 5, when the COVID-19 outbreak occurred in Bethlehem.
At first, no more than 50 people will be allowed in the Church, according to a joint statement from the churches that run the Church.
Kissing and touching stones, including in the cave where Jesus Christ is believed to have been born, will be prohibited.