Chemists from the University of Miami and their colleagues from the University of Michigan have created a new three-strand artificial enzyme. This study may help to create medicines in the future faster and cheaper.
Previously, Michigan researchers created simpler synthetic metal enzymes that successfully catalyzed several chemical reactions. But they were designed with three identical symmetrical strands, which limited the catalytic possibilities.
The peculiarity of the molecule that was created this time is that the third thread is different in structure from the other two. Quantum-mechanical calculations showed that a more complex structure expands the catalytic characteristics of artificial metalloenzymes.
“Our methods are different, but complement each other,” said researchers from Miami. We model molecules on a computer so that we can predict the structural properties and the mechanism of their formation. In Michigan, they use our models to determine their real functions”.
Scientists noted that their goal is to create new artificial enzymes that can emulate natural analogues on an industrial scale. For example, they can help create new drugs faster, cheaper, and more efficiently.