Scientists have found neurons in the brain that control the desire to eat: the effect on them can help people fight obesity.
Scientists were able to stimulate mice to eat less or more than usual by affecting a mechanism in their brain.
During the work, the authors noticed that the activity of these groups of DA-VTA neurons, which produce dopamine, and DRD1-LPBN, which regulate food intake, increase dramatically before the mice finish eating. Then the researchers tried to interfere with the work of this mechanism.
Biologists suppressed the activity of neurons, as a result, the mice began to gorge themselves. Conversely, artificial stimulation of these neurons discouraged mice from any desire for food. This means that the effect on the brain prevented the satiety response.
According to scientists, based on the data from the researchers, it will be possible to create drugs that help people in the fight against obesity.
The authors suggest that in humans, the satiety sensory system works in a similar way, since the low-level neural mechanisms are often the same.