The 3D model will help destroy the DNA of cancer cells. The results of a study by scientists from the Institute of Leukemia Joseph Carreras, which in the future will help prevent the development of malignant tumors, are published in the journal Epigenetics.
Often, promising cancer treatments are pointless for use in patients in real clinical settings. This happens despite the fact that many of them prove their effectiveness at the preclinical stage of testing in laboratories.
One explanation is that many of the tumor models used in the early stages of research are established cell lines that have grown for several decades in two-dimensional culture flasks. These cancer cells may not fully correspond to the characteristics of real tumors that develop in the bodies of patients.
In a new study, scientists created 3D models of cancer cells called organoids. They allow you to model the modifications that occur in the DNA of cells after being converted to tumor cells – and accelerate the development of effective anti-cancer drugs.
Our work solves the problem of unmet biomedical needs in the field of cancer research, which concerns the characteristics of the epigenetic imprint of human cancer organoids. The study shows that tumor models can be very useful for the biomedical research community and pharmaceutical companies developing anti-cancer drugs.
Manel Esteller, lead author of the research
Previously, the FDA approved a personal genome screening method for cancer diagnosis.